Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31092008 | 0.85 | HSP90AA1 (0.37) | MAPK1ALDH1A1KDM4EADRB2HPGD | |
| SCHEMBL28741889 | 0.74 | NT5E (0.44) | HSD17B10ALDH1A1KDM4EFABP4 | |
| SCHEMBL31091993 | 0.68 | DHODH (0.34) | CDK2 | |
| SCHEMBL3872027 | 0.66 | ADRB2 (0.48) | HSD17B10MAPK1ALDH1A1KDM4EADRB2 | |
| SCHEMBL3864885 | 0.61 | MAPT (0.45) | HSD17B10MAPK1ALDH1A1KDM4EADRB2 | |
| SCHEMBL28741778 | 0.61 | GRM4 (0.33) | — | |
| SCHEMBL23599273 | 0.59 | KMT2A (0.53) | HSD17B10MAPK1ALDH1A1KDM4ETP53 | |
| SCHEMBL28437830 | 0.59 | CRHBP (0.58) | HSD17B10MAPK1ALDH1A1KDM4ETP53 | |
| SCHEMBL30545002 | 0.59 | CRHBP (0.58) | HSD17B10MAPK1ALDH1A1KDM4ETP53 | |
| SCHEMBL1285136 | 0.59 | ADRB2 (0.53) | HSD17B10MAPK1KDM4EADRB2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |