Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730695 | 1.00 | LMNA (0.48) | LMNATSHRPDK1PDK2PDK3 | |
| SCHEMBL19923181 | 0.85 | SLC6A3 (0.59) | LMNATSHRPDK1PDK2PDK3 | |
| SCHEMBL7625221 | 0.81 | PDK1 (0.51) | LMNATSHRPDK1PDK2PDK3 | |
| SCHEMBL29279663 | 0.81 | TSHR (0.52) | LMNATSHRSLC6A3ALDH1A1CFTR | |
| SCHEMBL993113 | 0.81 | TSHR (0.59) | LMNATSHRPDK1PDK2PDK3 | |
| SCHEMBL28259053 | 0.81 | MEN1 (0.44) | TSHRPDK1PDK2PDK3PDK4 | |
| SCHEMBL27797134 | 0.81 | TSHR (0.59) | TSHRPDK2ALDH1A1HSD17B10CA1 | |
| SCHEMBL29433258 | 0.80 | TSHR (0.61) | LMNATSHRSLC6A3ALDH1A1CFTR | |
| SCHEMBL23659 | 0.80 | TSHR (0.61) | LMNATSHRSLC6A3ALDH1A1CFTR | |
| SCHEMBL2196615 | 0.79 | PTGS2 (0.55) | LMNATSHRPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126860-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | Janssen Pharmaceutica NV (BE) | 2023-02-08 | — | — | EP | disclosed |
| EP-3994137-A1 | HETEROCYCLIC MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2022-05-11 | — | — | EP | disclosed |