Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LIG1 | P18858 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29746274 | 0.83 | SLC6A3 (0.50) | TSHRLMNAMAPT | |
| SCHEMBL25233661 | 0.78 | MGLL (0.48) | DYRK1APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2371284 | 0.77 | HNF4A (0.63) | TSHRHNF4APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL19923193 | 0.76 | TSHR (0.68) | TSHRLIG1HNF4AALDH1A1L3MBTL1 | |
| SCHEMBL29628511 | 0.76 | TSHR (0.46) | TSHRHNF4A | |
| SCHEMBL29746242 | 0.74 | TSHR (0.41) | TSHRDYRK1AHNF4APRKAB2PRKAG1 | |
| SCHEMBL17965677 | 0.74 | TSHR (0.52) | TSHRHNF4APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL29746218 | 0.72 | ALDH2 (0.44) | TSHRLIG1HNF4AALDH1A1L3MBTL1 | |
| SCHEMBL18190663 | 0.72 | GRIA1 (0.52) | TSHR | |
| SCHEMBL2574179 | 0.72 | MAPT (0.50) | TSHRHNF4APRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3997096-B1 | NEW HETEROCYCLIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2024-08-28 | — | — | EP | disclosed |
| US-20220242876-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2022-08-04 | — | — | US | disclosed |
| EP-3997096-A1 | NEW HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2022-05-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220242876-A1 | HETEROCYCLIC COMPOUNDS | CYP1B1, CYP1A1, CYP1A2 | TSHR 2107/4885LIG1 2004/4885DYRK1A 4404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.