Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 3/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.38 |
| ▸ | SLC2A3 | P11169 | 3/20 | 0.38 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.38 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.38 |
| ▸ | SLC2A4 | P14672 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30540334 | 0.83 | NT5E (0.60) | NT5EPIN1SLC2A1SLC2A3SLC2A2 | |
| SCHEMBL2712104 | 0.78 | KDM4E (0.49) | NT5EADORA2AADORA1KDM4EDGAT1 | |
| SCHEMBL4420000 | 0.78 | NT5E (0.49) | NT5EADORA2AADORA1KDM4EMEN1 | |
| SCHEMBL4214227 | 0.76 | NT5E (0.69) | NT5ESLC2A1SLC2A3SLC2A2SLC2A4 | |
| SCHEMBL11828378 | 0.76 | NT5E (0.51) | NT5EADORA2AADORA1KDM4EMAPT | |
| SCHEMBL23716945 | 0.76 | ADRB2 (0.55) | NT5EADORA2AADORA1KDM4EMEN1 | |
| SCHEMBL4744648 | 0.76 | PIN1 (0.41) | PIN1KDM4ELMNAAR | |
| SCHEMBL28019418 | 0.74 | NT5E (0.56) | NT5EADORA2AADORA1KDM4EDGAT1 | |
| SCHEMBL5561501 | 0.74 | PIN1 (0.49) | PIN1HSD17B14CYP11B2AR | |
| SCHEMBL2425907 | 0.74 | ADORA2A (0.58) | NT5EADORA2AADORA1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710434-A | Modulators of MAS-related G protein receptor X2 and related products and uses thereof | 伊赛恩特制药公司 | 2023-09-05 | — | — | CN | disclosed |
| EP-4232042-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087083-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |