SCHEMBL29633653

SCHEMBL29633653

CC(=O)OCCC(F)(F)Cc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.51
RECQL P46063 1/20 0.42
TSHR P16473 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
HIF1A Q16665 1/20 0.40
CES1 P23141 1/20 0.40
MMP8 P22894 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
PTPN1 P18031 2/20 0.38
PTPRC P08575 1/20 0.38
SLC18A3 Q16572 1/20 0.38
CTRB1 P17538 1/20 0.38
PPID Q08752 1/20 0.37
CHRM1 P11229 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2011672 0.77 ALDH1A1 (0.46) ALDH1A1TSHRHIF1ASLC18A3CHRM1
SCHEMBL16937449 0.76 ALDH1A1 (0.46) ALDH1A1TSHRSMN1; SMN2TDP1CHRM1
SCHEMBL21598306 0.75 ALDH1A1 (0.47) ALDH1A1TSHRHIF1ASLC18A3CHRM1
SCHEMBL28044400 0.74 CA12 (0.49) ALDH1A1TSHRPTPN1CTRB1PPID
SCHEMBL28028200 0.74 KEAP1 (0.50) SMN1; SMN2HIF1ACES1PTPN1
SCHEMBL25840112 0.74 ALDH1A1 (0.50) ALDH1A1RECQLTSHRSMN1; SMN2HIF1A
Benzene SCHEMBL19304565 0.73 ALDH1A1 (0.64) ALDH1A1TSHRSMN1; SMN2HIF1ATDP1
SCHEMBL4351183 0.73 ALDH1A1 (0.64) ALDH1A1TSHRSMN1; SMN2HIF1ATDP1
SCHEMBL111422 0.73 ALDH1A1 (0.64) ALDH1A1TSHRSMN1; SMN2HIF1ATDP1
SCHEMBL17440807 0.73 SIRT2 (0.33) ALDH1A1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119823001-A Urea compounds antagonizing LPA1 receptor 大正制药株式会社 2025-04-15 CN disclosed
CN-114206832-B Urea compounds antagonizing LPA1 receptor 大正制药株式会社 2025-04-04 CN disclosed
CN-114206832-A Urea compounds antagonizing LPA1 receptor 大正制药株式会社 2022-03-18 CN disclosed