SCHEMBL29633897

SCHEMBL29633897

CN(C(=O)OCC1c2ccccc2-c2ccccc21)C(Cc1cccc(Cl)c1)C(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CTSL P07711 1/20 0.39
EPHX2 P34913 1/20 0.36
RIPK1 Q13546 1/20 0.35
FABP7 O15540 2/20 0.35
FABP5 Q01469 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.35
MAPK1 P28482 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
KMT2A Q03164 2/20 0.33
HSD17B2 P37059 1/20 0.33
PNMT P11086 1/20 0.33
MAOB P27338 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29633793 0.91 EPHX2 (0.37) CTSLEPHX2RIPK1FABP7FABP5
SCHEMBL29633971 0.89 ADORA1 (0.39) FABP7FABP5MAPTNPSR1KMT2A
SCHEMBL29633698 0.89 FABP5 (0.39) FABP7FABP5KMT2A
SCHEMBL29633939 0.89 CTSS (0.39) EPHX2RIPK1KDM4EMAPTMAPK1
SCHEMBL15083374 0.88 FABP5 (0.40) EPHX2FABP7FABP5KMT2AMAOB
SCHEMBL30510417 0.88 FABP5 (0.40) EPHX2FABP7FABP5KMT2AMAOB
SCHEMBL29982970 0.88 FABP5 (0.40) EPHX2FABP7FABP5KMT2AMAOB
SCHEMBL31370627 0.88 FABP5 (0.40) EPHX2FABP7FABP5KMT2AMAOB
SCHEMBL16287587 0.88 FABP5 (0.40) EPHX2FABP7FABP5KMT2AMAOB
SCHEMBL29633881 0.88 FABP5 (0.40) EPHX2FABP7FABP5KMT2AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240376044-A1 METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2024-11-14 US disclosed
US-12071396-B2 Method for preparing aromatic amino acid derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-08-27 US disclosed
US-20220144762-A1 METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-05-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240376044-A1 METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE DDC, AADAT, TYR CTSL 2501/4885EPHX2 2165/4885RIPK1 4514/4885
US-20220144762-A1 METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE DDC, AADAT, TYR CTSL 2501/4885EPHX2 2165/4885RIPK1 4514/4885
US-12071396-B2 Method for preparing aromatic amino acid derivative DDC, AADAT, TYR CTSL 2501/4885EPHX2 2165/4885RIPK1 4514/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.