Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24408862 | 1.00 | POLB (0.49) | POLBGPR119HRH3OPRD1OPRK1 | |
| SCHEMBL24408911 | 0.83 | POLB (0.50) | POLBGPR119HRH3OPRD1OPRK1 | |
| SCHEMBL24408859 | 0.83 | POLB (0.44) | POLBGPR119OPRD1OPRK1KMT2A | |
| SCHEMBL29634721 | 0.83 | POLB (0.44) | POLBGPR119OPRD1OPRK1KMT2A | |
| SCHEMBL25390075 | 0.78 | GPR119 (0.49) | POLBGPR119HRH3OPRD1OPRK1 | |
| SCHEMBL31283120 | 0.78 | GPR119 (0.49) | POLBGPR119HRH3OPRD1OPRK1 | |
| SCHEMBL29634691 | 0.78 | GPR119 (0.54) | GPR119HRH3 | |
| SCHEMBL3491735 | 0.76 | EPHX2 (0.55) | POLBGPR119KMT2A | |
| SCHEMBL19839814 | 0.76 | KMT2A (0.50) | GPR119KMT2A | |
| SCHEMBL24408874 | 0.76 | GPR119 (0.46) | POLBGPR119HRH3KMT2AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |