Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24408859 | 1.00 | POLB (0.44) | POLBOPRD1OPRK1GPR119MEN1 | |
| SCHEMBL29634698 | 0.83 | TRPM8 (0.34) | — | |
| SCHEMBL29634693 | 0.83 | POLB (0.49) | POLBOPRD1OPRK1GPR119MEN1 | |
| SCHEMBL24408862 | 0.83 | POLB (0.49) | POLBOPRD1OPRK1GPR119MEN1 | |
| SCHEMBL13161934 | 0.80 | POLB (0.48) | POLBOPRD1OPRK1GPR119 | |
| SCHEMBL24408911 | 0.79 | POLB (0.50) | POLBOPRD1OPRK1GPR119MEN1 | |
| SCHEMBL12543252 | 0.78 | POLB (0.47) | POLBOPRD1OPRK1GPR119KMT2A | |
| SCHEMBL24409120 | 0.76 | GPR119 (0.45) | POLBOPRD1OPRK1GPR119 | |
| SCHEMBL31283120 | 0.73 | GPR119 (0.49) | POLBOPRD1OPRK1GPR119 | |
| SCHEMBL25390075 | 0.73 | GPR119 (0.49) | POLBOPRD1OPRK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |