Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29634721 | 0.83 | POLB (0.44) | — | |
| SCHEMBL29634697 | 0.75 | TRPM8 (0.35) | TRPM8EPHX2ACACBACACASCD | |
| SCHEMBL24408860 | 0.75 | HTR2C (0.35) | — | |
| SCHEMBL12541675 | 0.74 | ADRA1D (0.45) | TRPM8EPHX2ACACBSIGMAR1 | |
| SCHEMBL29634699 | 0.70 | ACACB (0.35) | TRPM8EPHX2ACACBACACA | |
| SCHEMBL29634703 | 0.68 | TRPM8 (0.34) | TRPM8EPHX2ACACBCNR1 | |
| SCHEMBL29634694 | 0.68 | TRPM8 (0.35) | TRPM8EPHX2ACACBACACACNR1 | |
| SCHEMBL21961916 | 0.67 | HDAC3 (0.36) | TRPM8EPHX2SIGMAR1 | |
| SCHEMBL3714343 | 0.67 | SCD (0.52) | TRPM8EPHX2ACACBSCDSIGMAR1 | |
| SCHEMBL16496123 | 0.67 | TRPM8 (0.64) | TRPM8EPHX2CNR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |