Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 6/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29634697 | 0.84 | TRPM8 (0.35) | ACACBACACAEPHX2TRPM8HRH3 | |
| SCHEMBL24409120 | 0.83 | GPR119 (0.45) | HRH3 | |
| SCHEMBL22495703 | 0.75 | TRPM8 (0.38) | ACACAKMT2AEPHX2TRPM8ALDH1A1 | |
| SCHEMBL24408823 | 0.75 | HTR2C (0.35) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29634726 | 0.75 | HTR2C (0.35) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29634698 | 0.70 | TRPM8 (0.34) | ACACBACACAEPHX2TRPM8 | |
| SCHEMBL24408911 | 0.70 | POLB (0.50) | KMT2AHRH3 | |
| SCHEMBL29634703 | 0.69 | TRPM8 (0.34) | ACACBKMT2AEPHX2TRPM8HRH3 | |
| SCHEMBL29634694 | 0.68 | TRPM8 (0.35) | ACACBACACAEPHX2TRPM8HRH3 | |
| SCHEMBL21961916 | 0.68 | HDAC3 (0.36) | KMT2AEPHX2TRPM8ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |