Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29635286 | 0.91 | HTT (0.41) | MAPTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29140074 | 0.88 | KMT2A (0.48) | MAPTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29635285 | 0.88 | HTT (0.42) | MAPTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL28796630 | 0.88 | HTT (0.45) | MAPTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29635289 | 0.85 | MAPT (0.50) | MAPTL3MBTL1ALDH1A1KMT2AHPGD | |
| SCHEMBL28796566 | 0.85 | KMT2A (0.43) | MAPTMEN1KMT2AHTT | |
| SCHEMBL29635288 | 0.84 | MAPT (0.46) | MAPTL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL29140079 | 0.76 | MAPT (0.44) | MAPTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29635284 | 0.76 | CNR2 (0.41) | MAPTALDH1A1NPSR1HPGDPOLB | |
| SCHEMBL29635287 | 0.75 | MEN1 (0.50) | MAPTL3MBTL1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114671868-B | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2023-03-31 | — | — | CN | claimed |
| CN-114671868-A | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2022-06-28 | — | — | CN | claimed |
| CN-114671868-B | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2023-03-31 | — | — | CN | disclosed |
| CN-114671868-A | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2022-06-28 | — | — | CN | disclosed |