Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29635286 | 0.91 | HTT (0.41) | HTTKMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL29635290 | 0.88 | MAPT (0.44) | HTTKMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL29140074 | 0.88 | KMT2A (0.48) | HTTKMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL28796630 | 0.88 | HTT (0.45) | HTTKMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL29635289 | 0.88 | MAPT (0.50) | KMT2AALDH1A1GAAMAPTMARK4 | |
| SCHEMBL28796566 | 0.85 | KMT2A (0.43) | HTTKMT2AMEN1MAPT | |
| SCHEMBL29635288 | 0.84 | MAPT (0.46) | KMT2AMEN1ALDH1A1GAAMAPT | |
| SCHEMBL29635284 | 0.82 | CNR2 (0.41) | HTTALDH1A1GAAMAPT | |
| SCHEMBL29635287 | 0.75 | MEN1 (0.50) | HTTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL29140110 | 0.74 | ALDH1A1 (0.43) | HTTKMT2AMEN1CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114671868-B | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2023-03-31 | — | — | CN | claimed |
| CN-114671868-A | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2022-06-28 | — | — | CN | claimed |
| CN-114671868-B | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2023-03-31 | — | — | CN | disclosed |
| CN-114671868-A | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2022-06-28 | — | — | CN | disclosed |