Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28796630 | 0.84 | HTT (0.45) | HTTALDH1A1MAPTGAAHPGD | |
| SCHEMBL29635285 | 0.82 | HTT (0.42) | HTTALDH1A1MAPTGAA | |
| SCHEMBL29635286 | 0.80 | HTT (0.41) | HTTALDH1A1MAPTGAA | |
| SCHEMBL29635290 | 0.76 | MAPT (0.44) | HTTALDH1A1POLBMAPTHPGD | |
| SCHEMBL29140074 | 0.76 | KMT2A (0.48) | HTTALDH1A1MAPTMGAMAMY1A | |
| SCHEMBL29635289 | 0.75 | MAPT (0.50) | CNR2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL28796566 | 0.73 | KMT2A (0.43) | HTTMAPT | |
| SCHEMBL29635288 | 0.72 | MAPT (0.46) | ALDH1A1POLBMAPTMGAMAMY1A | |
| SCHEMBL29140110 | 0.71 | ALDH1A1 (0.43) | CNR2CNR1HTTALDH1A1POLB | |
| SCHEMBL29635282 | 0.70 | MEN1 (0.38) | HTTALDH1A1ELANEMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114671868-B | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2023-03-31 | — | — | CN | claimed |
| CN-114671868-A | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2022-06-28 | — | — | CN | claimed |
| CN-114671868-B | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2023-03-31 | — | — | CN | disclosed |
| CN-114671868-A | Polysubstituted indolizine compound containing pyridone and preparation method and application thereof | 浙大城市学院 | 2022-06-28 | — | — | CN | disclosed |