Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.73 |
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | RAB9A | P51151 | 6/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.73 |
| ▸ | RELA | Q04206 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ACACA | Q13085 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ACP1 | P24666 | 6/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29636725 | 0.85 | NPC1 (1.00) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL707767 | 0.85 | NPC1 (1.00) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL27610819 | 0.83 | NPC1 (0.97) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6858674 | 0.83 | NPC1 (0.97) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL12393772 | 0.78 | KDM4E (0.85) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL18774821 | 0.74 | ALDH1A1 (0.72) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL710433 | 0.73 | NPC1 (0.71) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL16404354 | 0.72 | CYP1A2 (0.62) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL29636789 | 0.72 | MAPT (0.71) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6534318 | 0.72 | MAPT (0.71) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | claimed |
| WO-2024054807-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND TDP-43 MODULATORS | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-03-14 | — | — | WO | disclosed |
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | disclosed |