Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 1.00 |
| ▸ | RAB9A | P51151 | 10/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 2/20 | 1.00 |
| ▸ | RELA | Q04206 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | AR | P10275 | 2/20 | 0.61 |
| ▸ | ACP1 | P24666 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707767 | 1.00 | NPC1 (1.00) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27610819 | 0.98 | NPC1 (0.97) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6858674 | 0.98 | NPC1 (0.97) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12393772 | 0.92 | KDM4E (0.85) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29636718 | 0.85 | KDM4E (0.73) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12112870 | 0.84 | RAB9A (0.80) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL18774821 | 0.84 | ALDH1A1 (0.72) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30462967 | 0.84 | ALDH1A1 (0.73) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5539333 | 0.84 | ALDH1A1 (0.73) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL26613511 | 0.84 | KDM4E (0.72) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | claimed |
| CN-119930511-A | Method for synthesizing N-heterocyclic compound by manganese complex catalysis under mild condition | 浙江工业大学 | 2025-05-06 | — | — | CN | disclosed |
| CN-119403554-A | Therapeutic or prophylactic agent for amyotrophic lateral sclerosis | 东丽株式会社 | 2025-02-07 | — | — | CN | disclosed |
| CN-117229204-A | Method for preparing quinoline derivative by catalytic conversion of lignin by rhodium-based catalyst | 中国科学院大连化学物理研究所 | 2023-12-15 | — | — | CN | disclosed |
| CN-117003695-A | Preparation method of 2, 3-disubstituted quinoline derivative | 广东工业大学 | 2023-11-07 | — | — | CN | disclosed |
| CN-116648245-A | Tetrahydroquinoline derivative and medical application thereof | 东丽株式会社 | 2023-08-25 | — | — | CN | disclosed |
| WO-2022138888-A1 | TETRAHYDROQUINOLINE DERIVATIVE AND MEDICINAL USE THEREOF | 東レ株式会社 | 2022-06-30 | — | — | WO | disclosed |