Sugi Predict

Sugi Predict / Compounds / SCHEMBL707767

SCHEMBL707767

SCHEMBL707767

COc1ccc(-c2ccc3ccccc3n2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 10/20 1.00
▸ RAB9A P51151 10/20 1.00
▸ KDM4E B2RXH2 8/20 1.00
▸ ALDH1A1 P00352 6/20 1.00
▸ SMN1; SMN2 Q16637 6/20 1.00
▸ NFKB1 P19838 2/20 1.00
▸ NFKB2 Q00653 2/20 1.00
▸ RELA Q04206 2/20 1.00
▸ MEN1 O00255 3/20 0.61
▸ KMT2A Q03164 3/20 0.61
▸ AR P10275 2/20 0.61
▸ ACP1 P24666 2/20 0.59
▸ MAPT P10636 4/20 0.59
▸ HPGD P15428 3/20 0.59
▸ CYP3A4 P08684 2/20 0.59
▸ PKM P14618 2/20 0.59
▸ GMNN O75496 1/20 0.59
▸ TP53 P04637 1/20 0.59
▸ THPO P40225 1/20 0.59
▸ BLM P54132 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29636725 1.00 NPC1 (1.00) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL27610819 0.98 NPC1 (0.97) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL6858674 0.98 NPC1 (0.97) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL12393772 0.92 KDM4E (0.85) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL29636718 0.85 KDM4E (0.73) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL12112870 0.84 RAB9A (0.80) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL18774821 0.84 ALDH1A1 (0.72) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL30462967 0.84 ALDH1A1 (0.73) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL5539333 0.84 ALDH1A1 (0.73) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL26613511 0.84 KDM4E (0.72) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111116466-B Catalytic synthesis method of polysubstituted quinoline derivative 浙江万里学院 2023-02-10 — — CN claimed
CN-1038525-A The colour filter system of LCD HOECHST CELANESE CORP (US) 1990-01-03 — — CN claimed
US-20260083723-A1 THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS TORAY INDUSTRIES, INC. (JP) 2026-03-26 — — US disclosed
US-12570639-B2 Tetrahydroquinoline derivative and medicinal use thereof TORAY INDUSTRIES, INC. (JP) 2026-03-10 — — US disclosed
EP-4545079-A1 THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS Toray Industries, Inc. (JP) 2025-04-30 — — EP disclosed
US-20240116903-A1 TETRAHYDROQUINOLINE DERIVATIVE AND MEDICINAL USE THEREOF TORAY INDUSTRIES, INC. (JP) 2024-04-11 — — US disclosed
WO-2023249106-A1 THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS 東レ株式会社 2023-12-28 — — WO disclosed
WO-2023249107-A1 THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR PERIPHERAL NERVE DISORDER 東レ株式会社 2023-12-28 — — WO disclosed
WO-2023249105-A1 THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR DRUG-INDUCED MYOCARDIAL DISORDERS 東レ株式会社 2023-12-28 — — WO disclosed
CN-117229204-A Method for preparing quinoline derivative by catalytic conversion of lignin by rhodium-based catalyst 中国科学院大连化学物理研究所 2023-12-15 — — CN disclosed
EP-4269392-A1 TETRAHYDROQUINOLINE DERIVATIVE AND MEDICINAL USE THEREOF Toray Industries, Inc. (JP) 2023-11-01 — — EP disclosed
CN-100357302-C Phosphorescent compound and element comprising same UNIVERSAL DISPLAY CORP (US) 2007-12-26 — — CN disclosed
CN-1589307-A Phosphorescent compounds and devices comprising the same UNIVERSAL DISPLAY CORP (US) 2005-03-02 — — CN disclosed
US-6835469-B2 Phosphorescent compounds and devices comprising the same THE UNIVERSITY OF SOUTHERN CALIFORNIA 2004-12-28 — — US disclosed
US-20040242615-A1 Utilities of olefin derivatives SHIONOGI & CO., LTD. (JP) 2004-12-02 — — US disclosed
WO-2003033617-A1 PHOSPHORESCENT COMPOUNDS AND DEVICES COMPRISING THE SAME UNIVERSAL DISPLAY CORPORATION (US) 2003-04-24 — — WO disclosed
US-20030072964-A1 Phosphorescent compounds and devices comprising the same TRUSTEES OF PRINCETON UNIVERSITY, THE 2003-04-17 — — US disclosed
US-4058532-A 1-Phenyl-3,4-dihydrocarbostyrils STERLING DRUG INC. (US) 1977-11-15 — — US disclosed
US-4049715-A 3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols STERLING DRUG INC. (US) 1977-09-20 — — US disclosed
US-3994902-A Certain 1,2-diphenyl-1,2,3,4-tetrahydroquinoline compounds STERLING DRUG INC. (US) 1976-11-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040242615-A1 Utilities of olefin derivatives APOL1, NR1H2, APOB NPC1 19/4885RAB9A 4723/4885KDM4E 4415/4885
US-20240116903-A1 TETRAHYDROQUINOLINE DERIVATIVE AND MEDICINAL USE THEREOF AIFM2, TXNRD2, NFE2L2 NPC1 579/4885RAB9A 1151/4885KDM4E 2935/4885
US-20260083723-A1 THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS AIFM2, GPX1, SOD1 NPC1 532/4885RAB9A 1524/4885KDM4E 2176/4885
US-12570639-B2 Tetrahydroquinoline derivative and medicinal use thereof AIFM2, GPX1, GPX4 NPC1 134/4885RAB9A 1155/4885KDM4E 1759/4885
US-20030072964-A1 Phosphorescent compounds and devices comprising the same NUDC, ORC3, PAICS NPC1 3932/4885RAB9A 2256/4885KDM4E 3023/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.