Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638325 | 0.85 | TP53 (0.39) | PIK3CATP53GAAEGFRPIK3CG | |
| SCHEMBL29638412 | 0.85 | AKR1C3 (0.44) | TP53L3MBTL1GAANPC1RAB9A | |
| SCHEMBL24557361 | 0.85 | MAPT (0.45) | NOX4PRKDCGAANPC1RAB9A | |
| SCHEMBL29638464 | 0.84 | NPC1 (0.41) | TP53L3MBTL1GAANPC1RAB9A | |
| SCHEMBL24557258 | 0.84 | NPC1 (0.41) | TP53L3MBTL1GAANPC1RAB9A | |
| SCHEMBL24557263 | 0.84 | TYK2 (0.39) | GAAMAPTFYNSRCJAK1 | |
| SCHEMBL29638451 | 0.84 | TYK2 (0.39) | GAAMAPTFYNSRCJAK1 | |
| SCHEMBL29638352 | 0.83 | ABCG2 (0.37) | TP53GAAEGFRFYNMAPK13 | |
| SCHEMBL24557308 | 0.83 | TYK2 (0.40) | GABRG2GABRB3GABRA5PIK3CAPRKDC | |
| SCHEMBL29638404 | 0.83 | TYK2 (0.40) | GABRG2GABRB3GABRA5PIK3CAPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |