Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PRKDC | P78527 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638473 | 1.00 | TYK2 (0.40) | TYK2POLBPIK3CAPRKDCPDE4A | |
| SCHEMBL29638512 | 0.89 | PLK1 (0.42) | TYK2PIK3CAPRKDCMTOR | |
| SCHEMBL24557357 | 0.89 | PLK1 (0.42) | TYK2PIK3CAPRKDCMTOR | |
| SCHEMBL29638437 | 0.87 | HPGD (0.40) | TYK2KDM4EALDH1A1 | |
| SCHEMBL24557258 | 0.86 | NPC1 (0.41) | TYK2POLBALDH1A1FYN | |
| SCHEMBL29638464 | 0.86 | NPC1 (0.41) | TYK2POLBALDH1A1FYN | |
| SCHEMBL29638414 | 0.85 | TYK2 (0.35) | TYK2POLB | |
| SCHEMBL24557251 | 0.84 | JAK2 (0.37) | TYK2PIK3CAPRKDCMTOR | |
| SCHEMBL29638468 | 0.84 | TRPV1 (0.39) | TYK2KDM4E | |
| SCHEMBL29638415 | 0.84 | JAK2 (0.37) | TYK2PIK3CAPRKDCMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |