Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 6/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24557251 | 1.00 | JAK2 (0.37) | JAK2JAK1JAK3PIK3CAPRKDC | |
| SCHEMBL24557311 | 0.89 | PLK1 (0.41) | PRKDCABCG2TYK2MAP3K12 | |
| SCHEMBL29638431 | 0.89 | PLK1 (0.41) | PRKDCABCG2TYK2MAP3K12 | |
| SCHEMBL29638437 | 0.87 | HPGD (0.40) | TYK2MAPTCYP1A2HPGDCYP2C19 | |
| SCHEMBL29638464 | 0.86 | NPC1 (0.41) | TYK2BTKMAPTLYNSRC | |
| SCHEMBL24557258 | 0.86 | NPC1 (0.41) | TYK2BTKMAPTLYNSRC | |
| SCHEMBL24557293 | 0.86 | CYP11B2 (0.37) | TYK2 | |
| SCHEMBL24557313 | 0.86 | CYP11B1 (0.35) | PRKDCABCG2TYK2 | |
| SCHEMBL29638460 | 0.86 | CYP11B2 (0.37) | TYK2 | |
| SCHEMBL29638434 | 0.86 | CYP11B1 (0.35) | PRKDCABCG2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |