Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.35 |
| ▸ | LCK | P06239 | 5/20 | 0.35 |
| ▸ | TEK | Q02763 | 4/20 | 0.35 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638623 | 0.84 | KDM1A (0.38) | BRAFLCKTEKRAF1KDR | |
| SCHEMBL29638749 | 0.79 | BRAF (0.38) | BRAFLCKTEKKDR | |
| SCHEMBL29638645 | 0.79 | BRAF (0.33) | BRAFLCKTEKRAF1KDR | |
| SCHEMBL26373249 | 0.77 | BRAF (0.40) | BRAFLCKTEKRAF1KDR | |
| SCHEMBL29638490 | 0.76 | MAPK14 (0.31) | BRAFRAF1 | |
| SCHEMBL29638510 | 0.74 | BRAF (0.47) | BRAFLCKTEKRAF1KDR | |
| SCHEMBL29638669 | 0.72 | TNNI3K (0.35) | KDRMAP4K4TDP1 | |
| SCHEMBL29638518 | 0.69 | FGFR1 (0.36) | BRAFRAF1KDRCYP1A2ALDH1A1 | |
| SCHEMBL25378146 | 0.68 | RAB9A (0.37) | BRAFLCKTEKRAF1CYP1A2 | |
| SCHEMBL29638578 | 0.67 | RAF1 (0.43) | BRAFRAF1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022089219-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-05-05 | — | — | WO | disclosed |