Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638339 | 0.83 | TYK2 (0.45) | TYK2JAK1 | |
| SCHEMBL24557363 | 0.83 | TYK2 (0.45) | TYK2JAK1 | |
| SCHEMBL29638423 | 0.83 | TYK2 (0.59) | TYK2JAK1 | |
| SCHEMBL29638455 | 0.81 | PIK3CA (0.35) | TYK2 | |
| SCHEMBL29638372 | 0.77 | TYK2 (0.42) | TYK2JAK1PSEN1PSEN2APH1B | |
| SCHEMBL29638329 | 0.75 | FGFR4 (0.36) | TYK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL25243633 | 0.75 | TYK2 (0.47) | TYK2JAK1PSEN1PSEN2APH1B | |
| SCHEMBL29638444 | 0.75 | TYK2 (0.38) | TYK2JAK1 | |
| SCHEMBL24557269 | 0.74 | TYK2 (0.40) | TYK2JAK1 | |
| SCHEMBL29638416 | 0.74 | TYK2 (0.40) | TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |