Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 4/20 | 0.33 |
| ▸ | LCK | P06239 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638518 | 0.90 | FGFR1 (0.36) | MAPK1PIM1FLT3PIM3PIM2 | |
| SCHEMBL29638578 | 0.86 | RAF1 (0.43) | BRAFGRM4EGFRRAF1CSF1R | |
| SCHEMBL29638706 | 0.78 | RAF1 (0.45) | BRAFEGFRRAF1CSF1RDDR1 | |
| SCHEMBL29638669 | 0.78 | TNNI3K (0.35) | PIM1PIM2KDR | |
| SCHEMBL29638490 | 0.77 | MAPK14 (0.31) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL29638629 | 0.77 | RAF1 (0.41) | BRAFEGFRRAF1CSF1RDDR1 | |
| SCHEMBL24399614 | 0.75 | ADORA2A (0.46) | PIM1FLT3PIM3PIM2BRAF | |
| SCHEMBL29638645 | 0.75 | BRAF (0.33) | BRAFLCKRAF1CSF1RDDR1 | |
| SCHEMBL29638581 | 0.74 | RAF1 (0.43) | PIM1PIM2BRAFGRM4EGFR | |
| SCHEMBL24399762 | 0.72 | DHFR (0.40) | PIM1PIM2BRAFLCKADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022089219-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-05-05 | — | — | WO | disclosed |