Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29640074 | 0.90 | CYP11B2 (0.34) | CYP11B2KCNH2NPC1KDM4ERECQL | |
| SCHEMBL12076615 | 0.70 | CYP11B2 (0.62) | CYP11B2KDM4ERECQLLTA4H | |
| SCHEMBL29640159 | 0.68 | KCNH2 (0.52) | CYP11B2KCNH2LTA4H | |
| SCHEMBL3920302 | 0.64 | PARP1 (0.38) | CYP11B2KCNH2KDM4ERECQLPARP1 | |
| SCHEMBL21617954 | 0.64 | ACACB (0.46) | NPC1ACACB | |
| Hydrochloric Acid SCHEMBL23928889 | 0.63 | ACACB (0.45) | NPC1ACACB | |
| Hydrochloric Acid SCHEMBL30587434 | 0.63 | ACACB (0.45) | NPC1ACACB | |
| SCHEMBL26347764 | 0.63 | ALDH1A1 (0.51) | — | |
| SCHEMBL28546476 | 0.61 | CYP11B2 (0.59) | CYP11B2 | |
| SCHEMBL30753095 | 0.60 | EPHX2 (0.33) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |