Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 5/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.35 |
| ▸ | CCR2 | P41597 | 4/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31091993 | 0.77 | DHODH (0.34) | ROCK1CDC7CCNE1CDK2DBF4 | |
| SCHEMBL29640162 | 0.68 | DGAT1 (0.34) | — | |
| SCHEMBL31091998 | 0.67 | ADRB2 (0.37) | MEN1KMT2AMAPK1 | |
| SCHEMBL30540536 | 0.67 | LMNA (0.40) | ROCK1CDC7DBF4ROCK2CCR2 | |
| SCHEMBL10850431 | 0.66 | NT5E (0.42) | ROCK1ALDH1A1 | |
| Lithium SCHEMBL31115361 | 0.63 | KDM4E (0.38) | ROCK1CDC7DBF4ROCK2CCR2 | |
| SCHEMBL30577604 | 0.63 | GRM2 (0.41) | ROCK2MEN1KMT2AALDH1A1GRM2 | |
| SCHEMBL30577588 | 0.63 | GRM2 (0.41) | ROCK2MEN1KMT2AALDH1A1GRM2 | |
| SCHEMBL30577649 | 0.63 | HRH3 (0.38) | ROCK1CDC7DBF4ROCK2CCR2 | |
| Lithium Ion SCHEMBL30540622 | 0.62 | LMNA (0.39) | ROCK1CDC7DBF4ROCK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |