Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35211500 | 0.75 | METAP2 (0.39) | NT5ENOS1TRPA1TRPM8TRPV1 | |
| SCHEMBL6850243 | 0.74 | SLC2A1 (0.44) | NOS1HTTPTK2SLC2A1DYRK1A | |
| SCHEMBL29864632 | 0.71 | NOS1 (0.34) | NOS1TRPA1TRPM8TRPV1METAP2 | |
| SCHEMBL31091998 | 0.70 | ADRB2 (0.37) | METAP2ADRB2 | |
| SCHEMBL10846163 | 0.70 | TLR7 (0.57) | HTTSLC2A1 | |
| SCHEMBL10847105 | 0.69 | GPR35 (0.41) | NOS1ALDH1A1HSD17B10 | |
| SCHEMBL35211775 | 0.68 | METAP2 (0.39) | NT5ENOS1TRPA1TRPM8TRPV1 | |
| SCHEMBL29626644 | 0.67 | METAP2 (0.44) | NOS1TRPA1TRPM8TRPV1METAP2 | |
| SCHEMBL21851687 | 0.67 | METAP2 (0.37) | TRPA1TRPM8METAP2ALDH1A1GAA | |
| SCHEMBL10124513 | 0.67 | METAP2 (0.44) | NOS1TRPA1TRPM8TRPV1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |