Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276823 | 1.00 | CYP2A6 (0.56) | CYP2A6MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL1801896 | 0.75 | CYP2A6 (0.50) | CYP2A6MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL4381193 | 0.74 | CYP2A6 (0.54) | CYP2A6MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL27287015 | 0.73 | ALDH1A1 (0.46) | CYP2A6MAPTERN1CNR2ALDH1A1 | |
| SCHEMBL264791 | 0.72 | CYP2A6 (0.52) | CYP2A6MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL5858617 | 0.71 | MAPT (0.41) | CYP2A6MAPTALDH1A1HSD17B10CA1 | |
| SCHEMBL4243900 | 0.71 | ALDH1A1 (0.53) | MAPTALDH1A1HSD17B10SMN1; SMN2CA1 | |
| SCHEMBL2248829 | 0.71 | CYP2A6 (1.00) | CYP2A6MAPTHDAC1HDAC6IDO1 | |
| SCHEMBL5370456 | 0.70 | ERN1 (0.56) | CYP2A6MAPTHDAC2ERN1ALDH1A1 | |
| SCHEMBL31148941 | 0.70 | PTPN22 (0.45) | CYP2A6MAPTERN1CNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12084418-B2 | Small molecule inhibitors of G(alpha)i2 protein and uses thereof | CLARK ATLANTA UNIVERSITY, INC. (US) | 2024-09-10 | — | — | US | disclosed |
| US-20220340526-A1 | Small Molecule Inhibitors of G(alpha)i2 Protein and Uses Thereof | GEORGIA TECH RESEARCH CORPORATION | 2022-10-27 | — | — | US | disclosed |
| WO-2022140297-A1 | SMALL MOLECULE INHIBITORS OF G(ALPHA)I2 PROTEIN AND USES THEREOF | CLARK ATLANTA UNIVERSITY (US) | 2022-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12084418-B2 | Small molecule inhibitors of G(alpha)i2 protein and uses thereof | GDI2, GNAI3, GNAI2 | CYP2A6 3251/4885MAPT 4764/4885HDAC3 3791/4885 |
| US-20220340526-A1 | Small Molecule Inhibitors of G(alpha)i2 Protein and Uses Thereof | GDI2, GNAI3, GNAI2 | CYP2A6 3251/4885MAPT 4764/4885HDAC3 3791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.