Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | FRK | P42685 | 2/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29640832 | 1.00 | MAPK9 (0.37) | MAPK9MAP4K4EGFRFRKCSNK1A1 | |
| SCHEMBL29640899 | 0.77 | LATS1 (0.37) | MAPK9MAP4K4EGFRFRKCSNK1A1 | |
| SCHEMBL26289615 | 0.76 | MEN1 (0.37) | MAP4K4RPS6KA5RPS6KA4MAPTMEN1 | |
| SCHEMBL30438289 | 0.76 | MEN1 (0.37) | MAP4K4RPS6KA5RPS6KA4MAPTMEN1 | |
| SCHEMBL29627704 | 0.74 | HSP90AA1 (0.42) | MAPK9MAPK14RPS6KA5MAPK10GRM5 | |
| SCHEMBL6449580 | 0.74 | HSP90AA1 (0.42) | MAPK9MAPK14RPS6KA5MAPK10GRM5 | |
| SCHEMBL6101938 | 0.74 | KDM4E (0.59) | MAPTKMT2AGRM5HSP90AA1ALDH1A1 | |
| SCHEMBL2650448 | 0.74 | L3MBTL1 (0.49) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL30061028 | 0.74 | L3MBTL1 (0.49) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL30620644 | 0.73 | NPC1 (0.47) | RPS6KA5RPS6KA4KMT2AGRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502163-A | Ethynylheterocycles as RHO-related coiled coil kinase (ROCK) inhibitors | 安吉昂生物医药公司 | 2022-05-13 | — | — | CN | disclosed |