Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.59 |
| ▸ | GRM5 | P41594 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | CCR1 | P32246 | 3/20 | 0.50 |
| ▸ | CCR5 | P51681 | 3/20 | 0.50 |
| ▸ | CCR8 | P51685 | 3/20 | 0.50 |
| ▸ | METAP1 | P53582 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193223 | 0.84 | GRM5 (0.62) | KDM4EGRM5ALDH1A1TP53L3MBTL1 | |
| SCHEMBL2016421 | 0.82 | IDH1 (0.41) | TDP1GRM5 | |
| SCHEMBL30423972 | 0.82 | TDP1 (0.68) | KDM4ETDP1GRM5TP53L3MBTL1 | |
| SCHEMBL1442585 | 0.82 | TDP1 (0.68) | KDM4ETDP1GRM5TP53L3MBTL1 | |
| SCHEMBL776048 | 0.81 | KDM4E (0.67) | KDM4ETDP1GRM5ALDH1A1TP53 | |
| SCHEMBL6535291 | 0.81 | TDP1 (0.44) | KDM4ETDP1GRM5TP53CCR1 | |
| SCHEMBL12824407 | 0.79 | KDM4E (0.71) | KDM4ETDP1GRM5ALDH1A1TP53 | |
| SCHEMBL4490247 | 0.78 | CCR1 (0.63) | KDM4ETDP1GRM5ALDH1A1TP53 | |
| SCHEMBL29545764 | 0.78 | CCR1 (0.63) | KDM4ETDP1GRM5ALDH1A1TP53 | |
| SCHEMBL9489007 | 0.78 | L3MBTL1 (0.65) | KDM4ETDP1GRM5ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005082884-A2 | 2-PYRIDIN-2YL-PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF GASTRO-ESOPHAGEA L REFLUX DISEASE | ASTRAZENECA AB (SE) | 2005-09-09 | — | — | WO | claimed |
| CN-102482232-A | Novel pyrimidine and triazine hepcidin antagonists | VIFOR INT AG | 2012-05-30 | — | — | CN | disclosed |
| US-7015228-B2 | 4-amino-2-(2-pyridyl)pyrimidines as microbicidal active substances | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2006-03-21 | — | — | US | disclosed |
| WO-2005082884-A2 | 2-PYRIDIN-2YL-PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF GASTRO-ESOPHAGEA L REFLUX DISEASE | ASTRAZENECA AB (SE) | 2005-09-09 | — | — | WO | disclosed |
| WO-2005082884-A2 | 2-PYRIDIN-2YL-PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF GASTRO-ESOPHAGEA L REFLUX DISEASE | ASTRAZENECA AB (SE) | 2005-09-09 | — | — | WO | disclosed |
| EP-1254903-B1 | 4-Amino-2-(pyridin-2-yl)pyrimidine as microbicidal active substances | CIBA SC HOLDING AG (CH) | 2005-06-08 | — | — | EP | disclosed |
| US-20030092718-A1 | 4-amino-2-(2-pyridyl)pyrimidines as microbicidal active substances | CIBA SPECIALTY CHEMICALS CORP. | 2003-05-15 | — | — | US | disclosed |
| EP-1254903-A1 | 4-Amino-2-(pyridin-2-yl)pyrimidine as microbicidal active substances | Ciba SC Holding AG (CH) | 2002-11-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092718-A1 | 4-amino-2-(2-pyridyl)pyrimidines as microbicidal active substances | CCR1, CCR2, CCRL2 | KDM4E 2832/4885TDP1 1153/4885GRM5 1704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.