Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | FABP2 | P12104 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12517362 | 0.91 | CYP19A1 (0.59) | CYP19A1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL26673955 | 0.87 | CYP19A1 (0.56) | CYP19A1HPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL2511132 | 0.86 | CA12 (0.53) | HPGDALDH1A1MAOAMAOBGSTP1 | |
| SCHEMBL11529553 | 0.85 | GAA (0.60) | CYP19A1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16701110 | 0.85 | SRD5A2 (0.57) | CYP19A1NR4A2MAPK1SRD5A2GSTP1 | |
| SCHEMBL12516200 | 0.85 | CYP19A1 (0.54) | CYP19A1HPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL12517355 | 0.84 | CYP19A1 (0.54) | CYP19A1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16364112 | 0.83 | CYP19A1 (0.53) | CYP19A1HPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL14901648 | 0.83 | ALDH1A1 (0.53) | CYP19A1HPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20305297 | 0.82 | ALDH1A1 (0.54) | CYP19A1CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240000951-A1 | GPX4 PROTEIN DEGRADATION-INDUCING COMPOUND | UPPTHERA (KR) | 2024-01-04 | — | — | US | disclosed |
| WO-2022119362-A1 | GPX4 PROTEIN DEGRADATION-INDUCING COMPOUND | (주) 업테라 | 2022-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240000951-A1 | GPX4 PROTEIN DEGRADATION-INDUCING COMPOUND | GPX4, GPX1, CRBN | CYP19A1 3112/4885HPGD 3320/4885CHRNB2 3893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.