Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31149975 | 0.92 | MAPT (0.37) | MAPTTHRBHSP90AB1JAK2KDM5B | |
| SCHEMBL29645797 | 0.90 | JAK2 (0.32) | THRBJAK2KDM5BFLT3P2RX7 | |
| SCHEMBL31150076 | 0.90 | JAK2 (0.33) | MAPTJAK2KDM5BJAK1TYK2 | |
| SCHEMBL29646040 | 0.88 | JAK2 (0.31) | JAK2KDM5BFLT3P2RX7 | |
| SCHEMBL29645600 | 0.88 | PDK2 (0.32) | JAK2KDM5BTYK2P2RX7ADORA3 | |
| SCHEMBL29645692 | 0.88 | BRD4 (0.32) | JAK2KDM5BTYK2 | |
| SCHEMBL29645717 | 0.87 | FLT3 (0.32) | JAK2KDM5BJAK1TYK2FLT3 | |
| SCHEMBL29645480 | 0.87 | MAPT (0.42) | MAPTTHRBKMT2AADORA3 | |
| SCHEMBL29645811 | 0.86 | SLC40A1 (0.34) | JAK2FLT3P2RX7 | |
| SCHEMBL29645864 | 0.84 | MAPT (0.40) | MAPTTHRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114466850-B | [1,2,4] Triazolo [1,5-C ] quinazolin-5-amine | 拜耳股份有限公司 | 2024-09-10 | — | — | CN | claimed |
| CN-114466850-A | [1,2,4] triazolo [1,5-C ] quinazolin-5-amines | 拜耳股份有限公司 | 2022-05-10 | — | — | CN | claimed |