Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29645421 | 0.92 | TTK (0.31) | — | |
| SCHEMBL31149932 | 0.92 | THRB (0.33) | JAK2KDM5BADORA3AURKBAURKA | |
| SCHEMBL31150076 | 0.90 | JAK2 (0.33) | JAK2KDM5BADORA3AURKBAURKA | |
| SCHEMBL29645601 | 0.90 | MAPT (0.35) | JAK2KDM5BADORA3FLT3THRB | |
| SCHEMBL29645810 | 0.90 | ADORA3 (0.35) | ADORA3METADORA2ATP53ADORA1 | |
| SCHEMBL29645600 | 0.88 | PDK2 (0.32) | JAK2KDM5BADORA3AURKBAURKA | |
| SCHEMBL29646040 | 0.88 | JAK2 (0.31) | JAK2KDM5BAURKBAURKALIMK1 | |
| SCHEMBL29645692 | 0.88 | BRD4 (0.32) | JAK2KDM5BAURKBAURKALIMK1 | |
| SCHEMBL29646030 | 0.87 | KMT2A (0.35) | JAK2KDM5BADORA3ADORA2ATHRB | |
| SCHEMBL29645717 | 0.87 | FLT3 (0.32) | JAK2KDM5BAURKBFLT3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114466850-B | [1,2,4] Triazolo [1,5-C ] quinazolin-5-amine | 拜耳股份有限公司 | 2024-09-10 | — | — | CN | claimed |
| CN-114466850-A | [1,2,4] triazolo [1,5-C ] quinazolin-5-amines | 拜耳股份有限公司 | 2022-05-10 | — | — | CN | claimed |