Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.64 |
| ▸ | MAOA | P21397 | 7/20 | 0.62 |
| ▸ | MAOB | P27338 | 7/20 | 0.62 |
| ▸ | PRKCI | P41743 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 2/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1091324 | 1.00 | GRM5 (0.64) | GRM5MAOAMAOBPRKCIPGR | |
| SCHEMBL1031985 | 0.89 | GRM5 (0.62) | GRM5MAOAMAOBPRKCIPGR | |
| SCHEMBL29741348 | 0.89 | GRM5 (0.62) | GRM5MAOAMAOBPRKCIPGR | |
| SCHEMBL29649358 | 0.86 | MAOB (0.62) | GRM5MAOAMAOBPRKCIPGR | |
| SCHEMBL4219924 | 0.86 | MAOB (0.62) | GRM5MAOAMAOBPRKCIPGR | |
| SCHEMBL389575 | 0.83 | MAOA (0.70) | GRM5MAOAMAOBPRKCIPGR | |
| SCHEMBL19548369 | 0.81 | MAOB (0.46) | GRM5MAOAMAOBPRKCIPGR | |
| SCHEMBL12063336 | 0.79 | MIF (0.52) | GRM5MAOAMAOBPGRCYP11B2 | |
| SCHEMBL4324503 | 0.79 | CYP11B2 (0.47) | GRM5MAOAMAOBPGRCYP11B2 | |
| SCHEMBL27913249 | 0.78 | DRD2 (0.52) | GRM5MAOAMAOBCYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118510758-A | RXFP1 agonists | 百时美施贵宝公司 | 2024-08-16 | — | — | CN | disclosed |
| WO-2024140431-A1 | COMPOUNDS COMPRISING HETEROARYL RINGS AND COMPOSITIONS AND METHODS THEREOF | IONGEN THERAPEUTICS CO., LTD. (CN) | 2024-07-04 | — | — | WO | disclosed |
| CN-114149457-B | Benzo [ c ] [1,2] oxaborole-1 (3H) -alcohol compound and application thereof | 湖北民族大学 | 2024-04-12 | — | — | CN | disclosed |
| US-20220306635-A1 | TDO2 Inhibitors | GENENTECH, INC. | 2022-09-29 | — | — | US | disclosed |
| CN-110072864-B | TDO2 inhibitors | 基因泰克公司 | 2022-05-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220306635-A1 | TDO2 Inhibitors | TDO2, IDO2, IDO1 | GRM5 2413/4885MAOA 26/4885MAOB 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.