Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28242090 | 1.00 | KEAP1 (0.43) | KEAP1NFE2L2CYP2C19P2RY12KMT2A | |
| SCHEMBL3100559 | 0.79 | KEAP1 (0.51) | KEAP1NFE2L2CYP2C19P2RY12KMT2A | |
| SCHEMBL28054219 | 0.78 | KEAP1 (0.46) | KEAP1NFE2L2CYP2C19P2RY12KMT2A | |
| SCHEMBL3064020 | 0.77 | CYP2C19 (0.48) | KEAP1NFE2L2CYP2C19P2RY12KMT2A | |
| SCHEMBL6937180 | 0.76 | KMT2A (0.55) | KEAP1NFE2L2KMT2ANPC1MEN1 | |
| SCHEMBL5262605 | 0.75 | GRM5 (0.39) | KMT2AHTT | |
| SCHEMBL31226026 | 0.73 | ALDH1A1 (0.46) | KEAP1NFE2L2CYP2C19P2RY12KMT2A | |
| SCHEMBL9937548 | 0.73 | KEAP1 (0.51) | KEAP1NFE2L2KMT2AGAAMEN1 | |
| SCHEMBL28265798 | 0.73 | CYP2D6 (0.36) | KMT2ASMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL31225276 | 0.72 | CYP2C19 (0.46) | KEAP1NFE2L2CYP2C19P2RY12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024115549-A1 | ARYL- AND HETEROARYL-SULFONAMIDE DERIVATIVES AS CCR8 MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-06 | — | — | WO | disclosed |
| CN-117327103-A | Substituted pyrimido ring inhibitor and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-110573511-B | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-114703144-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114621222-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-06-14 | — | — | CN | disclosed |