Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15345494 | 0.87 | DRD3 (0.50) | MAPTGSK3BROCK1LMNATP53 | |
| SCHEMBL29652020 | 0.85 | GSK3B (0.50) | MAPTGSK3BROCK1LMNATP53 | |
| SCHEMBL8938754 | 0.78 | LMNA (0.53) | ROCK1LMNATP53MAPK1MEN1 | |
| SCHEMBL3233624 | 0.77 | DRD2 (0.47) | MAPTLMNAADRB1SIGMAR1ADRA2A | |
| SCHEMBL23864705 | 0.77 | DRD2 (0.47) | MAPTROCK1ALDH1A1ADRB1SMN1; SMN2 | |
| SCHEMBL25026229 | 0.76 | ALDH1A1 (0.55) | ROCK1LMNATP53MAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL10547839 | 0.76 | MAPK1 (0.51) | MAPTROCK1LMNATP53MAPK1 | |
| SCHEMBL10625689 | 0.75 | POLB (0.51) | MAPTGSK3BROCK1LMNATP53 | |
| SCHEMBL29542545 | 0.75 | ALDH1A1 (0.53) | MAPTROCK1LMNATP53MAPK1 | |
| SCHEMBL3905172 | 0.75 | ALDH1A1 (0.53) | MAPTROCK1LMNATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067534-B1 | Substituted anilinic piperidines as MCH selective antagonists | H. LUNDBECK A/S (DK) | 2006-06-27 | — | — | US | disclosed |