Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.36 |
| ▸ | LPL | P06858 | 8/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29652912 | 0.80 | DGAT1 (0.40) | DGAT1 | |
| SCHEMBL17258894 | 0.80 | DGAT1 (0.40) | DGAT1 | |
| SCHEMBL16637155 | 0.80 | LPL (0.36) | ROCK1LIPGLPLJAK2BTK | |
| SCHEMBL18805560 | 0.76 | JAK2 (0.36) | ROCK1LIPGLPLJAK2BTK | |
| SCHEMBL29003349 | 0.75 | ROCK1 (0.35) | ROCK1LIPGLPLJAK2BTK | |
| SCHEMBL29470635 | 0.75 | ROCK1 (0.35) | ROCK1LIPGLPLJAK2BTK | |
| SCHEMBL15450937 | 0.74 | LIPG (0.40) | ROCK1LIPGLPL | |
| SCHEMBL21191016 | 0.74 | ANPEP (0.40) | LIPGLPLANPEPLAP3ALOX5 | |
| SCHEMBL25656297 | 0.73 | LMNA (0.48) | ROCK1LIPGCXCR2 | |
| SCHEMBL27090098 | 0.73 | DGAT1 (0.40) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3592742-B1 | JAK INHIBITORS CONTAINING A 4-MEMBERED HETEROCYCLIC AMIDE | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2021-05-19 | — | — | EP | disclosed |