Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2965515 | 1.00 | KMT2A (0.50) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL26933077 | 0.84 | AMY1A (0.51) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL22925067 | 0.81 | CYP1A1 (0.53) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL2973278 | 0.77 | KDM4E (0.48) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL5394265 | 0.77 | ERN1 (0.54) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL2973281 | 0.77 | KDM4E (0.48) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL5394260 | 0.77 | ERN1 (0.54) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL11848327 | 0.77 | CYP1A1 (0.59) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL8245121 | 0.76 | CYP1A2 (0.46) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL8207538 | 0.75 | CYP1A1 (0.58) | KMT2AALDH1A1KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781445-B2 | Synthesis of indenoisoquinoliniums and methods of use | PURDUE RESEARCH FOUNDATION (US) | 2010-08-24 | — | — | US | disclosed |
| US-20080242692-A1 | Synthesis of Indenoisoquinoliniums and Methods of Use | PURDUE RESEARCH FOUNDATION | 2008-10-02 | — | — | US | disclosed |
| EP-1735281-A2 | SYNTHESIS OF INDENOISOQUINOLINIUMS AND METHODS OF USE | Purdue Research Foundation (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005089294-A2 | SYNTHESIS OF INDENOISOQUINOLINIUMS AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242692-A1 | Synthesis of Indenoisoquinoliniums and Methods of Use | INMT, QTRT1, QTRT2 | KMT2A 880/4885ALDH1A1 3097/4885KDM4E 1162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.