Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2973278 | 1.00 | KDM4E (0.48) | KDM4EALDH1A1L3MBTL1CYP1A2MAPT | |
| SCHEMBL15495288 | 0.88 | ALDH1A1 (0.40) | KDM4EALDH1A1L3MBTL1CYP1A2MAPT | |
| SCHEMBL2965510 | 0.77 | KMT2A (0.50) | KDM4EALDH1A1CYP1A2MAPTNPC1 | |
| SCHEMBL2965515 | 0.77 | KMT2A (0.50) | KDM4EALDH1A1CYP1A2MAPTNPC1 | |
| SCHEMBL5397183 | 0.76 | ERN1 (0.51) | KDM4EALDH1A1L3MBTL1CYP1A2MAPT | |
| SCHEMBL5397187 | 0.76 | ERN1 (0.51) | KDM4EALDH1A1L3MBTL1CYP1A2MAPT | |
| SCHEMBL26933077 | 0.76 | AMY1A (0.51) | KDM4EALDH1A1L3MBTL1CYP1A2MAPT | |
| SCHEMBL2967381 | 0.74 | HPGD (0.46) | KDM4EALDH1A1CYP1A2MAPTSMN1; SMN2 | |
| SCHEMBL2967378 | 0.74 | HPGD (0.46) | KDM4EALDH1A1CYP1A2MAPTSMN1; SMN2 | |
| SCHEMBL14958112 | 0.74 | MAPT (0.47) | KDM4EALDH1A1CYP1A2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781445-B2 | Synthesis of indenoisoquinoliniums and methods of use | PURDUE RESEARCH FOUNDATION (US) | 2010-08-24 | — | — | US | disclosed |
| US-20080242692-A1 | Synthesis of Indenoisoquinoliniums and Methods of Use | PURDUE RESEARCH FOUNDATION | 2008-10-02 | — | — | US | disclosed |
| EP-1735281-A2 | SYNTHESIS OF INDENOISOQUINOLINIUMS AND METHODS OF USE | Purdue Research Foundation (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005089294-A2 | SYNTHESIS OF INDENOISOQUINOLINIUMS AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242692-A1 | Synthesis of Indenoisoquinoliniums and Methods of Use | INMT, QTRT1, QTRT2 | KDM4E 1162/4885ALDH1A1 3097/4885L3MBTL1 2235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.