Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EIF4E | P06730 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655083 | 0.85 | TDP1 (0.55) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL29655271 | 0.82 | TDP1 (0.62) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL27963778 | 0.82 | ALDH1A1 (0.62) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL717794 | 0.82 | MAPT (0.71) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL204041 | 0.81 | ALDH1A1 (0.61) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL27774544 | 0.81 | ALDH1A1 (0.61) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL29655168 | 0.80 | ERN1 (0.45) | MAPTTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9808940 | 0.80 | MAPT (0.51) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL29655165 | 0.79 | TDP1 (0.54) | MAPTTDP1MEN1KMT2APOLB | |
| Nitrogen SCHEMBL28840099 | 0.78 | ALDH1A1 (0.58) | MAPTTDP1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843874-B | Phthalazine derivatives useful as inhibitors of PARP1, PARP2 and/or tubulin for the treatment of cancer | 加利福尼亚大学董事会 | 2022-05-27 | — | — | CN | disclosed |