SCHEMBL29655296

SCHEMBL29655296

CC[C@H](C)[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ NTSR2 O95665 4/20 0.58
▸ NTSR1 P30989 4/20 0.58
▸ SORT1 Q99523 3/20 0.58
▸ REN P00797 11/20 0.56
▸ AGTR1 P30556 1/20 0.55
▸ AGTR2 P50052 1/20 0.55
▸ LNPEP Q9UIQ6 2/20 0.52
▸ C5AR1 P21730 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29569038 0.94 NTSR2 (0.61) NTSR2NTSR1SORT1RENAGTR1
SCHEMBL29568664 0.93 REN (0.62) NTSR2NTSR1SORT1RENAGTR1
SCHEMBL29569380 0.93 REN (0.62) NTSR2NTSR1SORT1RENAGTR1
SCHEMBL29568867 0.93 REN (0.62) NTSR2NTSR1SORT1RENAGTR1
SCHEMBL29568825 0.92 REN (0.61) NTSR2NTSR1SORT1RENAGTR1
SCHEMBL29568543 0.92 C5AR1 (0.63) NTSR2NTSR1SORT1RENAGTR1
SCHEMBL29568811 0.91 REN (0.60) NTSR2NTSR1SORT1RENAGTR1
SCHEMBL30670298 0.91 AGTR1 (0.62) NTSR2NTSR1SORT1AGTR1AGTR2
SCHEMBL29701255 0.90 SLC6A2 (0.63) NTSR2NTSR1SORT1RENAGTR1
SCHEMBL29569641 0.90 REN (0.61) NTSR2NTSR1SORT1RENAGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240108040-A1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2024-04-04 — — US disclosed
US-11758933-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2023-09-19 — — US disclosed
EP-3368542-B1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2022-06-22 — — EP disclosed
US-11357246-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2022-06-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240108040-A1 HIGH INTENSITY SWEETENERS TAS2R40, TAS2R60, TAS1R1 NTSR2 772/4885NTSR1 810/4885SORT1 2293/4885
US-11357246-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 NTSR2 772/4885NTSR1 810/4885SORT1 2293/4885
US-11758933-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 NTSR2 772/4885NTSR1 810/4885SORT1 2293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback