SCHEMBL29655439

SCHEMBL29655439

Brc1cccc2[nH]c3ccc4c5ccccc5oc4c3c12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.45
ZAP70 P43403 1/20 0.45
SYK P43405 1/20 0.45
CCNB2 O95067 1/20 0.41
CCNE2 O96020 1/20 0.41
CDK1 P06493 1/20 0.41
CDK4 P11802 1/20 0.41
CCNB1 P14635 1/20 0.41
PRKACA P17612 1/20 0.41
PRKACG P22612 1/20 0.41
PRKACB P22694 1/20 0.41
CCND1 P24385 1/20 0.41
CCNE1 P24864 1/20 0.41
CDK2 P24941 1/20 0.41
CAMK2B Q13554 1/20 0.41
CAMK2G Q13555 1/20 0.41
CAMK2D Q13557 1/20 0.41
CCNB3 Q8WWL7 1/20 0.41
CAMK2A Q9UQM7 1/20 0.41
GABRP O00591 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28643524 1.00 JAK2 (0.45) JAK2ZAP70SYKCCNB2CCNE2
SCHEMBL24728587 0.87 JAK2 (0.53) JAK2ZAP70SYKGABRPGABRD
SCHEMBL18620355 0.84 JAK2 (0.44) JAK2ZAP70SYKCCNB2CCNE2
SCHEMBL18646916 0.84 PIM1 (0.45) JAK2ZAP70SYKCCNB2CCNE2
SCHEMBL29819648 0.83 GABRA1 (0.51) JAK2ZAP70SYKCDK4CCND1
SCHEMBL31846 0.83 GABRA1 (0.51) JAK2ZAP70SYKCDK4CCND1
SCHEMBL29655467 0.83 GABRA1 (0.51) JAK2ZAP70SYKCDK4CCND1
SCHEMBL23406933 0.79 ALOX5 (0.41) ALOX5PGRCDC14BCDC14AAHR
SCHEMBL31385571 0.79 ALOX5 (0.41) ALOX5PGRCDC14BCDC14AAHR
SCHEMBL14951860 0.79 L3MBTL1 (0.47) JAK2ZAP70SYKCCNB2CCNE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113372261-B Method for preparing 1-bromo/chloro carbazole and derivatives thereof 中国科学院兰州化学物理研究所 2023-06-27 CN disclosed
CN-113620811-B Halogenation method of aromatic compound 中国科学院兰州化学物理研究所 2022-05-24 CN disclosed