Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CCNC | P24863 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.49 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22686015 | 1.00 | POLB (0.55) | POLBCCNCCDK8EPHX2THRB | |
| SCHEMBL22686719 | 0.85 | POLB (0.58) | POLBEPHX2 | |
| SCHEMBL22687453 | 0.82 | EPHX2 (0.57) | POLBCCNCCDK8EPHX2 | |
| SCHEMBL23666145 | 0.82 | POLB (0.62) | POLBEPHX2 | |
| SCHEMBL22687451 | 0.82 | EPHX2 (0.54) | POLBEPHX2 | |
| SCHEMBL5220987 | 0.80 | USP30 (0.57) | CCNCCDK8THRBUSP30MALT1 | |
| SCHEMBL29656088 | 0.79 | POLB (0.56) | POLBEPHX2 | |
| SCHEMBL22686119 | 0.79 | POLB (0.56) | POLBEPHX2 | |
| SCHEMBL22686737 | 0.79 | USP30 (0.56) | CCNCCDK8THRBUSP30MALT1 | |
| SCHEMBL22685999 | 0.78 | DRD2 (0.63) | POLBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213074-A1 | ABHD12 INHIBITORS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2022-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213074-A1 | ABHD12 INHIBITORS AND METHODS OF MAKING AND USING SAME | ABHD12, SAMHD1, ABHD11 | POLB 919/4885CCNC 4401/4885CDK8 2577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.