Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28734098 | 0.78 | MAP4K4 (0.49) | GPR119HSD17B10AKT1KDM4EALDH1A1 | |
| SCHEMBL29656696 | 0.77 | HSD17B10 (0.41) | GPR119HSD17B10AKT1L3MBTL1KDM4E | |
| SCHEMBL29656855 | 0.77 | HSD17B10 (0.40) | HSD17B10AKT1L3MBTL1ALDH1A1GLA | |
| SCHEMBL25779773 | 0.75 | TRPV3 (0.45) | HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL29656502 | 0.73 | HSD17B10 (0.39) | HSD17B10AKT1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL28734077 | 0.72 | ALDH1A1 (0.43) | HSD17B10KDM4EALDH1A1GLAHPGD | |
| SCHEMBL29656940 | 0.71 | HDAC1 (0.58) | GRM2PARP1HDAC1GPR119RET | |
| SCHEMBL30126957 | 0.71 | GRM2 (0.52) | GRM2PARP1HDAC1GPR119RET | |
| SCHEMBL30126214 | 0.71 | GRM2 (0.52) | GRM2PARP1HDAC1GPR119RET | |
| SCHEMBL30126523 | 0.70 | GRM2 (0.51) | GRM2PARP1HDAC1GPR119RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109721620-B | HPK1 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-05-13 | — | — | CN | disclosed |