Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28734077 | 0.96 | ALDH1A1 (0.43) | TRPV3PRMT5LMNATHRBALDH1A1 | |
| SCHEMBL29656696 | 0.85 | HSD17B10 (0.41) | ALDH1A1HSD17B10HPGDKDM4EJAK2 | |
| SCHEMBL28734098 | 0.83 | MAP4K4 (0.49) | PRMT5ALDH1A1GAASMN1; SMN2HSD17B10 | |
| SCHEMBL29656855 | 0.83 | HSD17B10 (0.40) | PRMT5LMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL28734074 | 0.83 | HSD17B10 (0.48) | LMNATHRBALDH1A1NPSR1MEN1 | |
| SCHEMBL29656798 | 0.75 | GRM2 (0.49) | ALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL30565902 | 0.75 | PDE3B (0.51) | LMNAALDH1A1MEN1GAAKMT2A | |
| SCHEMBL12820628 | 0.75 | PDE3B (0.51) | LMNAALDH1A1MEN1GAAKMT2A | |
| SCHEMBL30592552 | 0.73 | HSD17B10 (0.47) | LMNAALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL17837831 | 0.73 | ALDH1A1 (0.50) | TRPV3PRMT5LMNATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109902-A1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF IN MEDICINE | 海思科医药集团股份有限公司 | 2023-06-22 | — | — | WO | disclosed |
| CN-109721620-B | HPK1 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-05-13 | — | — | CN | disclosed |