Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25779773 | 0.83 | TRPV3 (0.45) | HSD17B10PRMT5HPGDSMN1; SMN2KDM4E | |
| SCHEMBL30565902 | 0.82 | PDE3B (0.51) | MAP4K4AKT1HSD17B10SMN1; SMN2PDE3B | |
| SCHEMBL12820628 | 0.82 | PDE3B (0.51) | MAP4K4AKT1HSD17B10SMN1; SMN2PDE3B | |
| SCHEMBL3381645 | 0.82 | AKT1 (0.65) | AKT1HSD17B10HPGDKDM4EALDH1A1 | |
| SCHEMBL28734077 | 0.80 | ALDH1A1 (0.43) | HSD17B10PRMT5HPGDSMN1; SMN2KDM4E | |
| SCHEMBL30814321 | 0.79 | MAP4K4 (0.48) | MAP4K4CKS1BSKP1SKP2PRMT5 | |
| SCHEMBL29656798 | 0.78 | GRM2 (0.49) | AKT1HSD17B10HPGDKDM4EALDH1A1 | |
| SCHEMBL30814292 | 0.78 | MAP4K4 (0.46) | MAP4K4CKS1BSKP1SKP2PRMT5 | |
| SCHEMBL16347793 | 0.76 | MAP4K4 (0.48) | MAP4K4CKS1BSKP1SKP2PRMT5 | |
| SCHEMBL29656855 | 0.75 | HSD17B10 (0.40) | AKT1HSD17B10PRMT5ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109721620-B | HPK1 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-05-13 | — | — | CN | disclosed |