Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pratosartan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 15/20 | 1.00 |
| ▸ | AGTR2 | P50052 | 15/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1652186 | 0.86 | AGTR2 (0.90) | AGTR1AGTR2 | |
| Pratosartan SCHEMBL93595 | 0.85 | AGTR1 (0.73) | AGTR1AGTR2 | |
| SCHEMBL683741 | 0.84 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL683751 | 0.80 | AGTR1 (0.67) | AGTR1AGTR2 | |
| SCHEMBL683401 | 0.80 | AGTR1 (0.74) | AGTR1AGTR2 | |
| SCHEMBL683762 | 0.80 | AGTR1 (0.66) | AGTR1AGTR2 | |
| SCHEMBL683452 | 0.79 | AGTR1 (0.73) | AGTR1AGTR2 | |
| SCHEMBL7416052 | 0.77 | AGTR1 (0.63) | AGTR1AGTR2 | |
| SCHEMBL29392553 | 0.77 | AGTR1 (1.00) | AGTR1AGTR2 | |
| SCHEMBL684098 | 0.75 | AGTR1 (0.68) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49080-E1 | Glycoside derivatives and uses thereof | NOVARTIS AG (CH) | 2022-05-24 | — | — | US | disclosed |