Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4076046 | 0.81 | MMP12 (0.49) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL28873445 | 0.81 | SIGMAR1 (0.68) | OPRK1SIGMAR1POLBCYP1A2CYP2C9 | |
| SCHEMBL2221988 | 0.81 | ANPEP (0.48) | SIGMAR1POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2221986 | 0.81 | ANPEP (0.48) | SIGMAR1POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19498803 | 0.75 | OPRK1 (0.81) | OPRK1SIGMAR1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL18065715 | 0.73 | MMP12 (0.56) | SMN1; SMN2TSHR | |
| SCHEMBL2479744 | 0.72 | OPRK1 (0.55) | OPRK1SIGMAR1POLBSMN1; SMN2 | |
| SCHEMBL20689709 | 0.72 | SIGMAR1 (0.68) | OPRK1SIGMAR1MEN1KMT2AHTT | |
| SCHEMBL20689717 | 0.72 | SIGMAR1 (0.68) | OPRK1SIGMAR1MEN1KMT2AHTT | |
| SCHEMBL20689711 | 0.72 | SIGMAR1 (0.68) | OPRK1SIGMAR1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283332-A1 | USES OF ARGINASE INHIBITORS FOR MANAGING KIDNEY DISEASE AND CARDIOVASCULAR CONDITIONS | EMORY UNIVERSITY (US) | 2023-01-12 | — | — | WO | disclosed |
| CN-110123820-B | Arginase inhibitors and methods of use thereof | 阿斯利康公司 | 2022-05-31 | — | — | CN | disclosed |