Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ASPH | Q12797 | 2/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.37 |
| ▸ | PRKCI | P41743 | 4/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | AGER | Q15109 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17619234 | 1.00 | KDM4E (0.37) | KDM4EASPHKDM8PRKCIPDE3B | |
| SCHEMBL23234668 | 0.87 | HRH4 (0.33) | KDM4EASPHKDM8 | |
| SCHEMBL21198627 | 0.84 | KDM4E (0.38) | KDM4EASPHKDM8PRKCIPDE3B | |
| SCHEMBL17603745 | 0.83 | KDM4E (0.47) | KDM4EKDM4CATRALDH1A1MAPT | |
| SCHEMBL30898769 | 0.77 | NOS3 (0.48) | PRKCILIMK1KDM4CATRALDH1A1 | |
| SCHEMBL23234804 | 0.77 | PIK3C3 (0.37) | KDM4EASPHKDM8PRKCIALDH1A1 | |
| SCHEMBL20520321 | 0.76 | KDM4E (0.50) | KDM4EASPHKDM8PDE3BPDE3A | |
| SCHEMBL29008185 | 0.76 | NUDT1 (0.34) | ALDH1A1IKBKB | |
| SCHEMBL21608277 | 0.76 | NOS2 (0.52) | KDM4ELIMK1 | |
| SCHEMBL30590435 | 0.76 | SMN1; SMN2 (0.42) | KDM4ELIMK1KDM4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116171155-B | Pyrido [2,3-d ] pyrimidine-2 (1H) -ketone derivative, preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-116171155-A | Pyrido [2,3-d ] pyrimidine-2 (1H) -ketone derivative, preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-05-26 | — | — | CN | disclosed |
| WO-2022121839-A1 | PYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2022-06-16 | — | — | WO | disclosed |