SCHEMBL29664135

SCHEMBL29664135

NC(=O)c1cc(C(F)(F)F)ncc1Br

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.38
DGAT1 O75907 1/20 0.36
PARP1 P09874 5/20 0.36
CA2 P00918 1/20 0.35
CHKA P35790 1/20 0.35
ADORA3 P0DMS8 1/20 0.35
TSHR P16473 1/20 0.35
MC4R P32245 1/20 0.35
ADRA1A P35348 1/20 0.35
MC3R P41968 1/20 0.35
SYK P43405 2/20 0.35
MAPK8 P45983 1/20 0.34
MAPK10 P53779 1/20 0.34
CDC7 O00311 1/20 0.34
ASPH Q12797 1/20 0.33
CASP1 P29466 1/20 0.33
HSP90AA1 P07900 1/20 0.33
AURKA O14965 1/20 0.33
AURKB Q96GD4 1/20 0.33
GPR52 Q9Y2T5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2987993 1.00 KMT2A (0.38) KMT2ADGAT1PARP1CA2CHKA
SCHEMBL2990846 0.84 ASPH (0.45) CA2TSHRASPH
SCHEMBL30018797 0.84 ASPH (0.45) CA2TSHRASPH
SCHEMBL31696427 0.81 KDM4E (0.41) KMT2ADGAT1PARP1CA2CHKA
SCHEMBL28850941 0.80 POLB (0.34) KMT2A
SCHEMBL22542502 0.79 CASP1 (0.42) KMT2ACA2CASP1
SCHEMBL26337674 0.79 NNMT (0.42) KMT2APARP1CA2CHKASYK
SCHEMBL17293016 0.79 SOS1 (0.47) TSHR
Nitrous Acid SCHEMBL28850943 0.79 ASPH (0.41) CA2TSHRASPH
SCHEMBL30824163 0.79 SOS1 (0.47) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116157397-A Heterocyclylpyridines as novel fungicides 拜耳公司 2023-05-23 CN disclosed
EP-3999510-A1 IMIDAZOPYRIMIDINES AS EED INHIBITORS AND THE USE THEREOF The Regents Of The University Of Michigan (US) 2022-05-25 EP disclosed