Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DHPS | P49366 | 1/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24632282 | 1.00 | BRD4 (0.44) | BRD4L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL24512826 | 0.87 | AHR (0.51) | L3MBTL1POLBMAPTMEN1KMT2A | |
| SCHEMBL29665861 | 0.87 | AHR (0.51) | L3MBTL1POLBMAPTMEN1KMT2A | |
| SCHEMBL29316688 | 0.85 | BRD4 (0.43) | BRD4L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL29315568 | 0.81 | AHR (0.47) | L3MBTL1POLBMAPTMEN1KMT2A | |
| SCHEMBL24583722 | 0.81 | ATR (0.41) | BRD4L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL29696916 | 0.81 | ATR (0.41) | BRD4L3MBTL1POLBMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL2039646 | 0.80 | L3MBTL1 (0.56) | BRD4L3MBTL1DHPSCD38KDR | |
| SCHEMBL24513509 | 0.79 | TAS2R14 (0.43) | BRD4L3MBTL1POLBMAPTMEN1 | |
| SCHEMBL29665884 | 0.79 | TAS2R14 (0.43) | BRD4L3MBTL1POLBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259604-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022125636-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |