Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 8/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | F9 | P00740 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lonaprofen SCHEMBL2109183 | 1.00 | NCEH1 (0.56) | NCEH1LMNASMN1; SMN2NPC1TP53 | |
| SCHEMBL11810433 | 0.86 | LMNA (0.53) | NCEH1LMNASMN1; SMN2NPC1TP53 | |
| SCHEMBL11807492 | 0.84 | LMNA (0.55) | NCEH1LMNASMN1; SMN2NPC1TP53 | |
| SCHEMBL11807725 | 0.84 | NCEH1 (0.54) | NCEH1LMNASMN1; SMN2NPC1TP53 | |
| SCHEMBL11798018 | 0.84 | LMNA (0.51) | NCEH1LMNASMN1; SMN2NPC1TP53 | |
| SCHEMBL11804487 | 0.83 | LMNA (0.47) | NCEH1LMNASMN1; SMN2NPC1TP53 | |
| SCHEMBL11800432 | 0.82 | LMNA (0.49) | NCEH1LMNASMN1; SMN2NPC1TP53 | |
| SCHEMBL23368144 | 0.79 | TSHR (0.54) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL18331090 | 0.79 | TSHR (0.54) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL13390983 | 0.78 | MAPT (0.58) | NCEH1LMNASMN1; SMN2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110713489-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-05-31 | — | — | CN | disclosed |